Aspectos psicológicos e estratégias de enfrentamento evidenciados em pacientes com doenças cardiovasculares / Psychological aspects and coping strategies evidenced in patients with cardiovascular diseases

As doenças cardiovasculares (DCV) fazem parte de grupo de doenças crônicas e apresentam alto índice de mortalidade. Deste modo, representam grande demanda aos serviços hospitalares, contribuindo para um número alto de internações. Apesar dos grandes avanços tecnológicos e do conhecimento clínico, os aspectos psicológicos ainda são pouco conhecidos. Objetivo: A presente pesquisa tem como objetivo verificar a prevalência de alterações psicológicas entre pacientes com DCV em tratamento ambulatorial. Métodos: Trata-se de um estudo transversal descritivo-quantitativo. Foram aplicados um questionário sociodemográfico, o Inventário Breve de Sintomas (BSI), o Inventário de Depressão de Beck (BDI-II) e a Escala Brief Cope. A coleta de dados ocorreu entre o período de março a abril de 2022, exclusivamente no ambulatório do Hospital Estadual de Urgências de Goiás Dr. Valdomiro Cruz. As variáveis sociodemográficas e clínicas foram analisadas por estatística descritiva ­ frequência absoluta e relativa, média, mediana e desvio padrão (DP). Resultados: O estudo revelou uma prevalência de sintomas psicológicos entre pacientes com doenças cardiovasculares em tratamento ambulatorial. Conclusão: Os principais sintomas psicológicos evidenciados foram psicoticismo, ansiedade e depressão e as principais estratégias de coping foram suporte instrumental, suporte emocional e religiosidade

: Cardiovascular diseases (CVD) are part of a group of chronic diseases and have a high mortality rate. Thus, they represent a great demand for hospital services, representing a high number of hospitalizations. Despite the great technological advances and clinical knowledge, the psychological aspects are still little known. Objective: This research aims to verify the prevalence of psychological changes among patients with CVD undergoing outpatient treatment. Methodology: This is a descriptive-quantitative cross-sectional study. A sociodemographic questionnaire, the Brief Symptom Inventory (BSI), the Beck Depression Inventory (BDI-II) and the Brief Cope Scale were applied. Data collection took place between March and April 2022, exclusively at the outpatient clinic of the Hospital Estadual de Urgências de Goiás Dr. Valdomiro Cruz. Sociodemographic and clinical variables were accompanied by descriptive statistics ­ absolute and relative frequency, mean, median and standard deviation (SD). Results: The study revealed a prevalence of psychological alterations among patients with cardiovascular diseases in outpatient treatment. Conclusion: The main psychological symptoms evidenced were psychoticism, anxiety and depression and the main coping strategies were instrumental support, emotional support and religiosity

Asociación entre enfermedades cardiometabólicas y depresión en un hospital de referencia peruano / Association between cardiometabolic diseases and depression in a Peruvian reference hospital

INTRODUCCIÓN: Se ha postulado la relación entre la presencia de enfermedades cardiometabólicas con problemas de salud mental, en particular la depresión. OBJETIVOS: Determinar la asociación entre la presencia de enfermedades cardiometabólicas y la presencia de sintomatología depresiva evaluada mediante el cuestionario PHQ-9 en pacientes atendidos en consultorios externos de medicina interna del Hospital Nacional Hipólito Unanue. METODOLOGÍA: Estudio observacional, analítico, transversal. Se definió enfermedad cardiometabólica como la presencia de diabetes mellitus, hipertensión arterial, dislipidemia, y/u obesidad. Se utilizó el cuestionario PHQ-9 para evaluar la presencia de síntomas sugerentes de depresión. Se evaluó la asociación cruda y ajustada a posibles confusores. Para el análisis multivariado se utilizó un modelo de regresión de Poisson para hallar razones de prevalencia con sus respectivos intervalos de confianza al 95%. Se consideró un p<0,05 como estadísticamente significativo. Resultados: Se incluyeron 252 pacientes, de los que 205 (81,4%) presentaron enfermedades cardiometabólicas y 181 (71,9%) presentaron síntomas consistentes con algún grado de depresión. La presencia de enfermedades cardiometabólicas se asoció a síntomas depresivos tanto en el análisis crudo (RPc 1,43; IC 95% 1,08-1,89; p=0,012) como en el ajustado (RPa 1,31; IC 95% 1,00-1,71; p=0,048). Adicionalmente se encontró asociación entre el sexo femenino y sintomatología depresiva (RPa 1,35; IC 95% 1,11-1,63; p=0,002). CONCLUSIONES: La presencia de enfermedades cardiometabólicas se asoció con la presencia de síntomas depresivos en pacientes atendidos en la consulta externa de medicina interna. El abordaje de la salud mental debe ser parte integral del manejo multidisciplinario del paciente con enfermedad cardiometabólica.

INTRODUCTION: It has been postulated the relationship between presence of cardiometabolic diseases with mental health problems, particularly depression. Objectives: To determine the association between cardiometabolic diseases and presence of depressive symptoms, evaluated by PHQ-9 questionnaire, in patients attended at the outpatient clinic of internal medicine service at Hospital Nacional Hipolito Unanue. METHODS: Observational analytical cross-sectional study. Cardiometabolic disease was defined as the presence of diabetes mellitus, high blood pressure, dyslipidemia, and/or obesity. The PHQ-9 questionnaire was used to evaluate the presence of symptoms suggestive of depression. The association was evaluated crude and adjusted for possible confounders. For the multivariate analysis, a Poisson regression model was used to find prevalence ratios with their respective 95% confidence intervals. A p<0.05 was considered statistically significant. RESULTS: 252 patients were included, of which 205 (81,4%) presented cardiometabolic diseases and 181 (71,9%) presented symptoms consistent with some grade of depression. The presence of cardiometabolic diseases was associated with depressive symptoms both in the crude analysis (PRc 1.43; CI 95% 1.08-1.89; p=0.012) and in the adjusted one (PRa 1.31; CI 95% 1.00-1.71; p=0.048). Additionally, an association was found between female sex and depressive symptoms (PRa 1,35; CI 95% 1,11-1,63; p=0,002). CONCLUSIONS: The presence of cardiometabolic diseases was associated with the presence of depressive symptoms in patients seen at the outpatient clinic of internal medicine. The mental health approach should be an integral part of the multidisciplinary management for the patient with cardiometabolic disease.

Domínios analisados na avaliação da resiliência em indivíduos com doenças cardiovasculares crônicas: revisão de escopo / Domains analyzed in the assessment of resilience in individuals with chronic cardiovascular diseases: a scoping review / Dominios analizados en la evaluación de la resiliencia en individuos con enfermedades cardiovasculares crónicas: revisión de escopo

OBJETIVO: Mapear as evidências científicas sobre os instrumentos utilizados na avaliação da resiliência em indivíduos adultos com doenças cardiovasculares crônicas e explorar seus domínios. MÉTODO: Revisão de escopo para responder à questão: Quais os instrumentos ou questionários utilizados para avaliação da resiliência em indivíduos adultos com doenças cardiovasculares crônicas? Foi realizada pesquisa nas bases de dados LILACS, Scopus, Web of Science, Pubmed, CINAHL e literatura cinzenta. Os estudos foram adicionados ao gerenciador Mendeley e a seleção realizada por dois revisores independentes (Kappa=0.86). RESULTADOS: Foram identificados 164 estudos e incluídos 14, sendo utilizados seis instrumentos para avaliação da resiliência. A avaliação da resiliência ocorreu em indivíduos com cardiopatia isquêmica, infarto do miocárdio, acidente vascular cerebral e insuficiência cardíaca. CONCLUSÃO: Os instrumentos não são adaptados para uso em indivíduos com doenças cardiovasculares crônicas. Faz-se necessária a formulação de instrumentos específicos que contemplem domínios individuais, mas que considerem o contexto social deste indivíduo.

OBJECTIVE: To map the scientific evidence on the instruments used to assess resilience in adult individuals with chronic cardiovascular disease, and explore their domains. METHOD: A scoping review to meet the question: What are the instruments or questionnaires used to assess resilience in adult individuals with chronic cardiovascular disease? The search was conducted in LILACS, Scopus, Web of Science, Pubmed, CINAHL databases and the grey literature. Studies were uploaded to Mendeley and the selection was performed by two independent reviewers (Kappa=0.86). RESULTS: A total of 164 studies were identified and 14 were included; six instruments were used to assess resilience. The resilience assessment occurred in individuals with ischemic heart disease, myocardial infarction, stroke, and heart failure. CONCLUSION: The instruments were not adapted for use in individuals with chronic cardiovascular diseases. The development of specific instruments that include individual domains and consider the social context of these individuals is necessary.

OBJETIVO: Mapear la evidencia científica sobre los instrumentos utilizados para evaluar la resiliencia en adultos con enfermedades cardiovasculares crónicas y explorar sus dominios. MÉTODO: Revisión de escopo para responder a la pregunta: ¿Que instrumentos o cuestionarios se utilizan para evaluar la resiliencia en personas adultas con enfermedades cardiovasculares crónicas? Se realizó una búsqueda en las bases de datos LILACS, Scopus, Web of Science, Pubmed, CINAHL y literatura gris. Los estudios fueron agregados al medidor Mendeley y la selección fue realizada por dos revisores independientes (Kappa=0.86). RESULTADOS: Se identificaron 164 estudios y se incluyeron 14, utilizando seis instrumentos para evaluar la resiliencia. La evaluación de la resiliencia se llevó a cabo en personas con cardiopatía isquémica, infarto del miocardio, accidente vascular cerebral e insuficiencia cardíaca. CONCLUSIÓN: Los instrumentos no están adaptados para su uso en personas con enfermedades cardiovasculares crónicas. Es necesario formular instrumentos específicos que contemplen dominios individuales, pero que consideren el contexto social de este individuo.

Aromatherapy in Patients with Cardiovascular Diseases: A Systematic Review

Abstract Background Aromatherapy consists in the use of volatile aromatic compounds of plant essential oils. Application methods include massage, baths, and mainly inhalation. Lavender essential oil is considered the most effective treatment for emotional disorders, such as stress and anxiety, due to its anxiolytic and sedative agents, which are known to interfere with physiological cardiovascular reactions. Objectives To investigate the effects of aromatherapy using lavender essential oil on hemodynamic responses and emotional aspects of patients with cardiovascular diseases. Methods A systematic review was conducted using Embase, Bireme, MEDLINE, PEDro, and Scopus electronic databases. Randomized clinical trials that evaluated hemodynamic and emotional outcomes using interventions with lavender essential oil in patients with cardiovascular diseases were selected. Of 539 studies initially identified, 51 were read in full and only 5 were eligible for inclusion. Results Reductions were demonstrated in hemodynamic responses, such as systolic and diastolic blood pressure, mean arterial pressure, and heart rate, as well as a decrease in anxiety, depression, stress, and fatigue compared with the control group. Statistical significance was set at p<0.05. Conclusion: Aromatherapy with the use of lavender essential oil provided benefits to hemodynamic parameters, such as anxiety, stress, depression, and fatigue levels, in patients with cardiovascular diseases. (Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0)

Efecto de los factores de riesgo psicosociales relacionados al trabajo en el desarrollo de enfermedades cardiovasculares / The impact of work-related psychosocial risk factors on the development of cardiovascular diseases

Durante los últimos años, las enfermedades cardiovasculares (en adelante ECVs) en Chile se han situado como la primera causa de muerte y discapacidad. Frente a esta situación, el Ministerio de Salud ha generado programas de control de los factores de riesgo comunes para el desarrollo de enfermedades cardiovasculares. Sin embargo, no se ha considerado los factores de riesgo psicosociales relacionados con el trabajo, los que según la tendencia internacional se han validado como parte de los factores causantes de enfermedades cardiovasculares. Este documento tiene por objetivo evidenciar la importancia que tienen los factores de riesgos psicosociales laborales (en adelante FRPSL) para el desarrollo de ECVs, reflexionando sobre la experiencia en otros países y comparando esas realidades con la mirada actual en el control de las enfermedades cardiovasculares en Chile. Las experiencias revisadas validan a los factores de riesgo comunes como los principales para el desarrollo de enfermedades cardiovasculares, pero avalan que los factores de riesgo psicosociales de origen laboral mantienen una relación tanto directa como indirecta con el desarrollo y/o agravamiento de estas patologías, pese a que en Chile esto aún no se reconozca en términos legales. (AU)

In Chile, in recent years, cardiovascular diseases (hereinafter CVD) have been the leading cause of death and disability. Faced with this situation, the Ministry of Health has developed programs to control the common risk factors for the development of cardiovascular diseases, however, the work-related psychosocial risk factors have not been considered, which according to the international trend, have been validated as part of the causative factors of cardiovascular diseases.This study aims to highlight the importance of work-related psychosocial risk factors (hereinaf-ter PWF) for the development of CVD, reflecting on the experience in other countries, com-paring these realities with the current perspective in the control of cardiovascular diseases in Chile.The evidence confirms common risk factors as the key to the development of cardiovascular diseases. However, it guarantees that work-related psychosocial risk factors maintaining a relationship both directly and indirectly with the manifestation of these diseases, in despite of this is not recognized legally in Chile yet. (AU)

Trastornos afectivos y salud física, implicaciones de la comorbilidad con enfermedades médicas: una revisión de la literatura / Affective disorders and physical health, implications of comorbid medical conditions: a non-systematic review

INTRODUCCIÓN La comorbilidad médica en pacientes con trastornos del estado de ánimo tiende a convertirse en un problema de salud pública clínica y global cada vez más importante. Varias patologías médicas específicas están asociadas con un mayor riesgo de padecer trastornos del estado de ánimo y, por otra parte, los trastornos del estado de ánimo están asociados con un aumento de la morbilidad y mortalidad debidas a condiciones médicas comórbidas. En este artículo se revisan las comorbilidades médicas que más comúnmente se asocian a los trastornos afectivos (enfermedades cardiovasculares, obesidad y síndrome metabólico) examinando sus posibles implicaciones bidireccionales. MÉTODOS Se ha realizado una revisión no sistemática y búsqueda de la literatura científica sobre la asociación entre las tres enfermedades médicas más frecuentes en trastorno depresivo mayor y trastorno bipolar (enfermedades cardiovasculares, obesidad, síndrome metabólico) entre enero de 1995 y noviembre de 2019. RESULTADOS La evidencia sugiere que la comorbilidad entre estas tres enfermedades médicas y los trastornos del estado de ánimo es muy frecuente; la presencia de las primeras empeora significativamente el pronóstico y el manejo terapéutico de las segundas y viceversa, comparten mecanismos fisiopatológicos e implican una etiología aparentemente bidireccional. CONCLUSIONES La presencia de estas enfermedades médicas concurrentes en un individuo con un trastorno del estado de ánimo se asocia con una presentación de enfermedad más compleja. En muchos casos, estas comorbilidades pueden preceder a la aparición de los trastornos del estado de ánimo, aunque en la mayoría de los casos parecen seguir a la aparición de los trastornos del estado de ánimo. Para los profesionales, la evidencia apoya inequívocamente las recomendaciones para la vigilancia rutinaria de las comorbilidades según un enfoque multidisciplinar.

INTRODUCTION Medical comorbidity in patients with mood disorders tends to become an increasingly important clinical and global public health problem. On one hand, several specific medical pathologies are associated with an increased risk of mood disorders and on the other hand, mood disorders are associated with increased morbidity and mortality due to comorbid medical conditions. This article reviews the medical comorbidities that are most commonly associated with affective disorders (cardiovascular diseases, obesity and metabolic syndrome) examining their possible bidirectional implications. METHODS A non-systematic review about the association between the three most common medical diseases in major depressive disorder and bipolar affective disorder (cardiovascular diseases, obesity, metabolic syndrome) has been carried out from January 1995 to November 2019. RESULTS The evidence suggests that comorbidity between these three medical diseases and mood disorders is very prevalent. The presence of medical disease significantly worsens the prognosis and therapeutic management of the mood disorders and vice versa. In many cases, these comorbidities may precede the onset of mood disorders, although in most cases they appear to follow the onset of mood disorders. CONCLUSIONS the presence of these concurrent medical diseases in an individual with a mood disorder is associated with a more complex disease presentation. For professionals, the evidence unequivocally supports recommendations for routine surveillance of comorbidities according to a multidisciplinary approach.

Factores de riesgo cardiovascular no convencionales / Unconventional cardiovascular risk factor

Desde hace varias décadas se conocen los clásicos factores de riesgo cardiovascular (género, edad, hipertensión arterial, dislipidemias, tabaquismo, obesidad, sedentarismo). También existen factores de riesgo "no convencionales", es decir situaciones no descriptas ni contenidas en la mayoría de los puntajes de riesgo tradicionales, pero de las cuales existen evidencias científicas. En esta revisión se analizan algunos de ellos, tales como factores socioeconómicos, horarios prolongados de trabajo, factores ambientales, aislamiento social, cantidad y calidad del sueño. También hay factores de "protección" cardiovascular como la dieta mediterránea. La literatura cuenta con un número muy elevado de publicaciones que abarcan estos factores. En la presente descripción se incluyeron algunas que fuesen representativas, con buen diseño experimental y que hayan realizado análisis multivariado de los resultados para controlar potenciales confundidores que invaliden las conclusiones. Finalmente, se discuten los mecanismos fisiopatológicos involucrados en la generación de los eventos cardiovasculares finales. (AU)

The classical cardiovascular risk factors have been known for several decades (gender, age, arterial hypertension, dyslipidemia, smoking, obesity, sedentary lifestyle). There also exist "non conventional" risk factors, that are those not described or not included in the majority of the traditional cardiovascular risk scores, but for whom scientific evidence is available. In this review some of them are analyzed, such as socio economic factors, prolonged work schedules, environmental factors, social isolation, sleep quantity and quality. There are also some "preventive" cardiovascular factors as the Mediterranean diet. There exist considerable amount of publications in the literature analyzing these issues. In the present paper some of them are discussed. They have been selected as they were representative of the corresponding aspect, well designed and with multivariate statistical analysis of the results, in order to control potential confounders that could invalidate the conclusions. Finally, the pathophysiological mechanisms involved are discussed. (AU)

The association between personal history and the outcomes of transobturator sling surgery

SUMMARY OBJECTIVE: This study aims to verify the association between risk factors for the onset of SUI and transobturator suburethral sling surgical treatment outcomes. PATIENTS AND METHODS: A retrospective study was conducted with 57 patients operated by the Pelvic Floor Surgery Service. Demographic data were compiled from the sample, the body mass index (BMI) was calculated, and the patients were divided according to the response to the surgical treatment. RESULTS: A total of 77.2% of the sample was cured or improved after surgical treatment. Out of the total sample, 75.4% of the women were postmenopausal, and 73.7% denied current or past smoking. The median age was 61 years, the median number of births was 4.0, the median BMI was 28.6 kg/m2, and 50.9% of the sample was classified as pre-obese. BMI, menopausal status, age, smoking, and sexual activity were not factors associated with the surgical outcome. However, parity equal to or greater than 5 was associated with worse postoperative results (p = 0.004). CONCLUSIONS: among risk factors associated with the emergence of SUI, only parity greater than 4 showed a negative impact on transobturator sling surgery outcomes.

RESUMO OBJETIVO: O estudo pretende verificar a associação entre fatores de risco relacionados ao surgimento da IUE com resultado do tratamento cirúrgico com sling suburetral transobturador. PACIENTES E MÉTODOS: Foi realizado estudo retrospectivo com 57 pacientes operadas pelo serviço de Cirurgia do Assoalho Pélvico da FMJ. Foram compilados dados demográficos da amostra, calculado o índice de massa corpórea (IMC) e as pacientes foram divididas de acordo com a resposta ao tratamento cirúrgico. RESULTADOS: 77,2% da amostra apresentou-se curada ou melhorada após o tratamento cirúrgico, 75,4% das mulheres se encontravam na pós-menopausa e 73,7% negaram tabagismo atual ou passado. A mediana de idade foi de 61 anos, a mediana do número de partos foi de 4,0 e a mediana do IMC foi de 28,6 kg/m2; 50,9% da amostra foi classificada como pré-obesa. O IMC, o status menopausal, a idade, o tabagismo e a manutenção da atividade sexual não foram fatores associados ao resultado cirúrgico. Porém, a paridade igual ou superior a 5 associou-se a piores resultados pós-operatórios (p=0,004). CONCLUSÕES: Entre os fatores de risco associados ao surgimento da IUE, apenas a paridade maior que 4 influenciou negativamente as taxas de melhora após cirurgia de sling transobturador.

Prevalence of depression and anxiety and their association with cardiovascular risk factors in Northeast Brasil primary care patients

SUMMARY BACKGROUND: Depression and anxiety disorders (DAD) are the most prevalent mental health conditions worldwide. Among the adult population served in basic care, it is estimated that depression affects about 14.3% of these individuals worldwide, and between 21.4% and 31% in Brasil. Anxiety affects up to 33.7% of the population during their lifetimes. OBJECTIVES: estimate the prevalence proportions of DAD among patients in a municipality in Northeast Brasil and study the association between DAD and cardiovascular risk factors. METHODS: a cross-sectional study with the medical records of patients from primary care centers in Jaboatão dos Guararapes, Pernambuco. Patients aged ≥ 18 years and regularly followed-up were included. Exclusion criteria: a history of traumatic brain injury, alcohol or drug abuse, previous stroke, medical conditions or medications that mimic DAD symptoms. Subjects were divided into two groups depending on the presence or absence of DAD, and cardiovascular risk factors were compared between groups. RESULTS: A total of 1030 subjects were initially included, of whom 215 (20%) were excluded. No-DAD subjects had more history of myocardial infarction and alcoholism. The prevalence of depression was 10.3%, anxiety disorder was 27.1%, and mixed DAD represented 4.5%. There was a significant association between DAD and hypertension (OR = 2.11; 95%CI: 1.16 -3.84; p=0.01), obesity (OR = 4.47; 95%CI: 1.74 -11.46; p=0.002), and hyperlipidemia (OR = 3.88; 95%CI: 1.81-8.3; p<0.001). CONCLUSION: DAD were associated with an increased risk for arterial hypertension, obesity, and hyperlipidemia.

RESUMO INTRODUÇÃO: Transtornos de ansiedade e depressão (TAD) são os distúrbios psiquiátricos mais comuns no mundo. Dentre a população adulta atendida na atenção básica, estima-se que a depressão afete cerca de 14,3% desses indivíduos mundialmente, podendo este valor ir de 21,4% a 31% no Brasil. A ansiedade afeta até 33,7% da população durante sua vida. OBJETIVO: Estimar a prevalência de TAD em pacientes da atenção primária em um município do Nordeste brasileiro e associar sua ocorrência com fatores de risco cardiovasculares. MÉTODOS: Um estudo de coorte transversal com análise de prontuário de pacientes atendidos em unidades de saúde da família de Jaboatão dos Guararapes, Pernambuco. Foram incluídos pacientes ≥18 anos e acompanhados regularmente. Critérios de exclusão: história de trauma crânio encefálico, abuso de álcool e drogas, acidente vascular cerebral prévio, doenças ou medicações que mimetizem sintomas de TAD. Os indivíduos foram divididos em dois grupos, a depender da presença ou não de TAD, e os fatores de risco cardiovascular foram comparados entre os grupos. RESULTADOS: De um total de 1.030 indivíduos recrutados, 215 (20%) foram excluídos. O grupo não TAD apresentou mais história de infarto do miocárdio e etilismo. A prevalência de depressão foi de 10,3%, a de ansiedade foi de 27,1% e a associação entre os dois foi de 4,5%. Houve associação significativa entre TAD e hipertensão (OR = 2,11; IC95: 1,16-3,84; p=0,01), obesidade (OR = 4,47; IC95%: 1,74-11,46; p=0,002) e dislipidemia (OR = 3,88; IC95%: 1,81-8,3; p<0,001). CONCLUSÃO: TAD estão associados com maior risco de hipertensão arterial, obesidade e dislipidemia.

Sex-Related Effects of Prenatal Stress on Region-Specific Expression of Monoamine Oxidase A and β Adrenergic Receptors in Rat Hearts / Efeitos Sexo-Específicos de Estresse Pré-Natal na Expressão Região-Específica de Monoamina Oxidase A e Receptores Adrenérgicos Β no Coração de Ratos

Abstract Background: Prenatal stress may increase risk of developing cardiovascular disorders in adulthood. The cardiotoxic effects of catecholamines are mediated via prolonged adrenergic receptor stimulation and increased oxidative stress upon their degradation by monoamine oxidase A (MAO-A). Objectives: We investigated long-term effects of prenatal stress on β (1, 2, 3) adrenergic receptors and MAO-A gene expression in the hearts of adult rat offspring. Methods: Pregnant rats were exposed to unpredictable mild stress during the third week of gestation. RNA was isolated from left ventricular apex and base of adult offspring. Quantitative PCR was used to measure gene expression in collected ventricular tissue samples. The level of significance was set to p < 0.05. Results: β3 adrenergic receptor mRNA was undetectable in rat left ventricle. β1 adrenergic receptor was the predominantly expressed subtype at the apical and basal left ventricular myocardium in the control females. Male offspring from unstressed mothers displayed higher apical cardiac β1 than β2 adrenergic receptor mRNA levels. However, β1 and β2 adrenergic receptor mRNAs were similarly expressed at the ventricular basal myocardium in males. Unlike males, prenatally stressed females exhibited decreased β1 adrenergic receptor mRNA expression at the apical myocardium. Prenatal stress did not affect cardiac MAO-A gene expression. Conclusions: Collectively, our results show that prenatal stress may have exerted region- and sex-specific β1 and β2 adrenergic receptor expression patterns within the left ventricle.

Resumo Fundamento: Estresse pré-natal pode aumentar os riscos de desenvolver doenças cardiovasculares na idade adulta. Os efeitos cardiotóxicos de catecolaminas são mediados pela estimulação prolongada dos receptores adrenérgicos e pelo aumento do estresse oxidativo após sua degradação pela monoamina oxidase A (MAO-A). Objetivos: Investigamos os efeitos a longo prazo de estresse pré-natal nos receptores β (1, 2, 3) adrenérgicos e na expressão do gene MAO-A nos corações da prole adulta de ratos. Método: Ratas prenhes foram expostas a estresse crônico moderado imprevisível durante a terceira semana de gestação. O RNA foi isolado do ápice e da base do ventrículo esquerdo da prole adulta. Utilizou-se PCR quantitativa em tempo real para medir a expressão gênica nas amostras de tecido ventricular coletadas. O nível de significância foi estabelecido em p < 0,05. Resultados: Foi indetectável o mRNA do receptor adrenérgico β3 no ventrículo esquerdo dos ratos. O receptor adrenérgico β1 foi o subtipo mais expresso no miocárdio ventricular esquerdo apical e basal nas fêmeas controle. A prole masculina das mães não estressadas apresentou níveis cardíacos apicais de mRNA do receptor adrenérgico β1 mais altos do que os de β2. Porém, mRNAs dos receptores adrenérgicos β1 e β2 foram expressos de forma semelhante no miocárdio basal ventricular na prole masculina em geral. Ao contrário da prole masculina, a prole feminina exposta ao estresse pré-natal exibiu uma expressão diminuída do mRNA do receptor adrenérgico β1 no miocárdio apical. O estresse pré-natal não afetou a expressão gênica de MAO-A cardíaca. Conclusões: Coletivamente, nossos resultados mostram que estresse pré-natal pode ter exercido padrões de expressão região- e sexo-específica dos receptores adrenérgicos β1 e β2 no ventrículo esquerdo.

Estrés psicológico y síndrome metabólico / Longitudinal association between chronic psychological stress and metabolic syndrome

Background: Psychological stress and depressive symptoms are variables associated with metabolic syndrome (MetS). Aim: To determine the longitudinal association between psychological stress, depressive symptoms and MetS, and whether these variables predict MetS and its component trajectories. Material and Methods: Four hundred and twenty-three participants aged 44 ± 9 years (59% women), free of cardiovascular disease at baseline were enrolled into the Chilean study of psychological stress, obesity and MetS. Participants were followed-up for three years (three waves). Each year, they completed psychological questionnaires, anthropometric variables were measured, and blood samples were obtained. Results: Hierarchical linear regression showed that chronic psychological stress at baseline predicted the total number of MetS components (MetS score) during the third assessment wave (β = 0.147; p < 0.01). Growth curve modeling allowed to determine that participants who scored +1 standard deviation (SD) at baseline over the mean in psychological stress (βchronic stress = 0.903; 95% confidence intervals (CI) = 0.065; 1.741), and depressive symptoms (βdepressive symptoms = 2.482; 95% CI = 0.040; 4.923) had a higher waist circumference trajectory, as compared to those scoring −1 SD above the mean. Conclusions: Chronic psychological stress is longitudinally associated with the MetS score. Further, psychological stress and depressive symptoms at baseline predicted elevated MetS score trajectories, and a highest waist circumference.

Symptoms of anxiety and depression are related to cardiovascular responses to active, but not passive, coping tasks

Objective: Anxiety and depression have been linked to blunted blood pressure (BP) and heart rate (HR) reactions to mental stress tests; however, most studies have not included indices of underlying hemodynamics nor multiple stress tasks. This study sought to examine the relationships of anxiety and depression with hemodynamic responses to acute active and passive coping tasks. Methods: A total of 104 participants completed the Hospital Anxiety and Depression Scales and mental arithmetic, speech, and cold pressor tasks while BP, HR, total peripheral resistance, and cardiac output (CO) were assessed. Results: After adjustment for traditional risk factors and baseline cardiovascular activity, depression scores were negatively associated with systolic BP, HR, and CO responses to the mental arithmetic task, while anxiety scores were inversely related to the systolic BP response to mental arithmetic. Conclusion: High anxiety or depression scores appear to be associated with blunted cardiac reactions to mental arithmetic (an active coping task), but not to the cold pressor test or speech tasks. Future research should further examine potential mechanisms and longitudinal pathways relating depression and anxiety to cardiovascular reactivity. Clinical trial registration number: TCTR20160208004

Salivary cortisol and alpha-amylase: subclinical indicators of stress as cardiometabolic risk

Currently, the potential for cardiovascular (CV) stress-induced risk is primarily based on the theoretical (obvious) side effects of stress on the CV system. Salivary cortisol and α-amylase, produced respectively by the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic-adrenomedullary (SAM) system during stress response, are still not included in the routine evaluation of CV risk and require additional and definitive validation. Therefore, this article overviews studies published between 2010 and 2015, in which salivary cortisol and α-amylase were measured as stress biomarkers to examine their associations with CV/CMR (cardiometabolic risk) clinical and subclinical indicators. A comprehensive search of PubMed, Web of Science and Scopus electronic databases was performed, and 54 key articles related to the use of salivary cortisol and α-amylase as subclinical indicators of stress and CV/CMR factors, including studies that emphasized methodological biases that could influence the accuracy of study outcomes, were ultimately identified. Overall, the biological impact of stress measured by salivary cortisol and α-amylase was associated with CV/CMR factors. Results supported the use of salivary cortisol and α-amylase as potential diagnostic tools for detecting stress-induced cardiac diseases and especially to describe the mechanisms by which stress potentially contributes to the pathogenesis and outcomes of CV diseases.

Relación de la autoeficacia y la actividad física de los pacientes con enfermedad coronaría / Relationship between self-efficacy and physical activity in patients with coronary heart disease

Introducción. La enfermedad coronaria (EC) está causada por la sinergia de los factores de riesgo cardiovascular (FRCV) como la inactividad física, por lo que cobra gran importancia el cuidado de enfermería a través de la prevención secundaria, sin embargo, a pesar de que la autoeficacia (AE) ha mostrado ser efectiva y está relacionada con la modificación de FRCV existe variabilidad en las intervenciones, efectos y seguimiento. Objetivo. Analizar la relación que tiene la autoeficacia y la actividad física de los pacientes con enfermedad coronaria. Material y métodos. Se realizó un estudio no experimental, descriptivo y transversal. Muestra probabilística aleatoria simple(n=77) de pacientes adultos, ambos sexos tratados por primera vez de EC con FRCV y se eliminaron aquellos que no contestaron 100% del instrumento IPAQ y la escala de AE. Análisis de datos con estadística descriptiva y pruebas paramétricas y no paramétricas de acuerdo a distribución de datos; significancia p<0.05. Resultados. Mayoría hombres (83.6%), edad 53.87 ± 9.95 años, sobrepeso(45.9%), DM (23.8%), HAS (29.5%) y 63.9 nunca realizó actividad vigorosa, 54.1% moderada y 91.2% caminaba y permanecían sentados 256.34 ± 192.59 minutos. AE29.07 ± 5.11puntos, mismo que se relaciona con actividad física (r=0.276, r2=0.076, p=0.032), más con las mujeres (r=0.669, r2=0.448, p=0.034). Presentan más AE quienes practican un deporte (z=-2.56, p=0.010). Conclusiones. Los pacientes con EC presentan diversos FRCV considerados convencionales con una AF moderadamente vigorosa pero con muchas actividades sedentarias; así mismo, se perciben con una buena AE, misma que se relaciona con la AF.

Introduction. Coronary heart disease (CHD) is caused by the synergy of cardiovascular risk factors (CRFs) and physical inactivity, so it becomes very important the nursing care through secondary prevention, however, even though the self-efficacy has proved to be effective and it is related to the modification of the CRFs, there is variability in the interventions, and monitoring effects. Objective. Analyze the relationship between self-efficacy and physical activity of patients with coronary disease. Material and methods. It has been made a non-experimental, descriptive and cross-sectional study; a random probability sample (n = 77) of adult patients, both genders, treated for the first time against the CHD with the CRFs, and those who did not answer the 100% of the IPAQ instrument and scale of self-efficacy were eliminated; and a data analysis with descriptive statistics and parametric and non-parametric tests according to data distribution; significance of p <0.05. Results.Most men (83.6%), age 53.87 ± 9.95 years, overweight (45.9%), DM (23.8%), hypertension (29.5%) and 63.9 never made strenuous activity, 54.1% moderate and 91.2% walked and sat 256.34 ± 192.59 minutes. AE 29.07 ± 5.11puntos, same that relates to physical activity (r= 0.276, r2=0.076, p= 0.032), more with women (r= 0.669, r2= 0.448, p= 0.034). AE who have more in sport (z= -2.56, p= 0.010). Conclutions. CD patients have various conventional cardiovascular risk factors considered moderately vigorous with AF but with many sedentary activities; likewise, they perceive with a good AE, same that relates to the AF.

Grupo psicoeducativo en cuidados paliativos para el paciente cardiópata y su familia / Psychoeducational group in palliative care for cardiac patient and his family

El presente artículo tiene la finalidad de compartir la experiencia que ha tenido la Unidad de Cuidados Integrales Avanzados (UCIA) con la conformación de grupos a los que se les brinda atención psicoeducativa, como parte de los cuidados paliativos ofrecidos por el Instituto Nacional de Cardiología Ignacio Chávez. En la atención directa con los pacientes en situación de terminalidad y su familia se identificaron situaciones que afectan directamente su calidad de vida, razón por la cual se diseñó un programa para realizar intervención psicoeducativa con enfoque biopsicosocial a través de un equipo de salud transdisciplinar con el objetivo principal de ampliar el repertorio de afrontamiento del paciente y del cuidador principal a través de la orientación respecto a la enfermedad, síntomas y cuidados paliativos específicos que puede realizar en el hogar. Dicho programa cuenta con las políticas, normas y lineamientos de operación que considera el contexto actual de los pacientes en situación de terminalidad y de su familia. Se destacan aspectos importantes observados posterior a la psicoeducación tales como: identificación de conductas adaptativas, ampliación del repertorio de afrontamiento, disminución de las consultas en los servicios de urgencias y del número de hospitalizaciones.

This article aims to share the experience of the Comprehensive Care Unit (CCU) with the formation of groups that are given psychoeducational care, as part of the palliative care offered by the National Institute of Cardiology Ignacio Chavez. In direct care with terminally ill patients and their families, situations that directly affect their quality of life were identified, that is why a program was designed to carry out a psychoeducational intervention with a bio-psycho-social approach through a team of transdisciplinary health, with the main objective of expanding the repertoire for coping with the patient and the main caregiver through orientation regarding the illness, symptoms and specific palliative care that can be done at home. This program has the policies, rules and guidelines of operation that considers the current context of terminally ill patients and their family. Important aspects observed after psychoeducation are highlighted such as identification of adaptive behaviors, expansion of coping repertoire, reduction of visits to the emergency services and number of hospitalizations.

Psicocardiologia: análise de aspectos relacionados à prevenção e ao tratamento de doenças cardiovasculares / Psychocardiology: analysis of issues related to the prevention and treatment of cardiovascular diseases

Doenças Cardiovasculares (DCV) são atualmente a causa mais frequente de mortalidade no mundo, produzindo um sério impacto funcional e emocional na vida de pacientes e familiares. Configuram-se, assim, como um problema complexo e um desafio para a saúde pública. Diante da importância desta questão, diversas áreas do conhecimento se mobilizam para buscar alternativas de prevenção e desenvolver estratégias de tratamento mais eficazes. O objetivo do artigo é apresentar dados epidemiológicos sobre DCV, indicar fatores de risco e de proteção, descrever a Psicocardiologia, área recente e interdisciplinar entre a Psicologia e a Medicina e, por fim, apontar possibilidades de atuação de terapeutas comportamentais nesse contexto clínicos comportamentais podem contribuir na identificação de classes de comportamentos associados às DCV, manipular as variáveis antecendentes à sua emissão e as consequencias que selecionam e mantêm essa condição. Neste contexto, o paciente deve aprender a discriminar os determinantes de seus comportamentos para alterá-los...

Cardiovascular diseases (CVD) are currently the most frequent cause of mortality worldwide, producing serious functional and emotional impairment in patients and their families’ lives. Thus, this condicion is considered complex problem and a challenge to the public health system. Given the importance of this issue, several areas of knowledge are mobilized in order to develop prevention strategies and more effective treatment. The aim of the paper is to present epidemiological data on CVD , indicate risk and protective factors, describe Psychocardiology, a recent and interdisciplinary area between psychology and medicine, and finally, point treatment possibilities of behavioral therapists in this context. Behavioral clinicians can contribute to the identification of classes of behaviors associated with CVD, manipulate the antecedents variables for their issuance and the consequences that select and maintain this condition. In this context,the patient may learn to discriminate the determinants of his behavior in order to change them...

Anxiety, depression, resilience and self-esteem in individuals with cardiovascular diseases / Ansiedade, depressão, resiliência e autoestima em indivíduos com doenças cardiovasculares / Ansiedad, depresión, resiliencia y autoestima en individuos con enfermedades cardiovasculares

ABSTRACT Objectives: to analyze the relationship between anxiety and depression symptoms, resilience and self-esteem with sociodemographic and clinical characteristics; correlate resilience and self-esteem with age and duration of the disease; check associations between anxiety and depression with measures of resilience and self-esteem among individuals with cardiovascular diseases. Method: correlational study conducted in a large university hospital in the interior of the state of São Paulo, Brazil. The population was composed of adult inpatients with cardiovascular diseases. A non-probabilistic consecutive sample was composed of 120 patients. Variables of interest were assessed using the Hospital Anxiety and Depression Scale, Resilience Scale, and Rosenberg Self-Esteem Scale. Results: anxiety and depression symptoms were present in 32.5% and 17.5% of the patients, respectively, and were associated with the female sex (p = 0.002; p = 0.022). Manifestations of depression were associated with the presence of comorbidities (p = 0.020). More resilient patients did not present depression symptoms (p < 0.001) and anxious women were more resilient (p = 0.042). The highest scores regarding self-esteem were present in patients with anxiety and depression. Men presented higher resilience and lower self-esteem compared to women. Conclusion: patients with anxiety and depression were less resilient but presented higher self-esteem.

RESUMO Objetivos: analisar as relações entre os sintomas ansiosos e depressivos, resiliência e autoestima com as características sociodemográficas e clínicas; correlacionar resiliência e autoestima com a idade e o tempo da doença; analisar associações entre ansiedade e depressão com as medidas de resiliência e autoestima em indivíduos com doenças cardiovasculares. Método: estudo correlacional, realizado em Hospital de Ensino de grande porte do interior do Estado de São Paulo. A população era constituída por pacientes adultos internados com doenças cardiovasculares. Uma amostra consecutiva e não probabilística foi constituída por 120 pacientes. As variáveis de interesse foram avaliadas pela Escala Hospitalar de Ansiedade e Depressão, Escala de Resiliência e Escala de Autoestima de Rosenberg. Resultados: os sintomas de ansiedade e depressão estavam presentes em 32,5% e 17,5% dos pacientes, respectivamente e foram associados ao sexo feminino (p = 0,002; p = 0,022). As manifestações de depressão foram associadas à presença de comorbidades (p = 0,020). Pacientes mais resilientes não apresentaram sintomas depressivos (p < 0,001) e, as mulheres ansiosas, foram menos resilientes (p = 0,042). Os maiores escores de autoestima estiveram presentes em pacientes com ansiedade e depressão. Os homens apresentaram maior resiliência e menor autoestima quando comparados às mulheres. Conclusão: pacientes com ansiedade e depressão foram menos resilientes e apresentaram maior autoestima.

RESUMEN Objetivos: analizar las relaciones entre los síntomas ansiedad y depresión, resiliencia y autoestima, con las características sociodemográficas y clínicas; correlacionar la resiliencia y autoestima con la edad y el tiempo de la enfermedad; analizar asociaciones entre ansiedad y depresión con las medidas de resiliencia y autoestima en individuos con enfermedades cardiovasculares. Método: estudio de correlación, realizado en un Hospital de Enseñanza de gran porte del interior del estado de Sao Paulo. La población estuvo constituida por pacientes adultos internados con enfermedades cardiovasculares. Una muestra consecutiva y no probabilística fue constituida por 120 pacientes. Las variables de interés fueron evaluadas por la Escala Hospitalaria de Ansiedad y Depresión, la Escala de Resiliencia y la Escala de Autoestima de Rosenberg. Resultados: los síntomas de ansiedad y depresión estaban presentes en 32,5% y 17,5% de los pacientes, respectivamente y fueron asociados al sexo femenino (p = 0,002; p = 0,022). Las manifestaciones de depresión fueron asociadas a la presencia de comorbilidades (p = 0,020). Pacientes más resilientes no presentaron síntomas depresivos (p < 0,001) y, las mujeres ansiosas, fueron menos resilientes (p = 0,042). Los mayores puntajes de autoestima estuvieron presentes en pacientes con ansiedad y depresión. Los hombres presentaron mayor resiliencia y menor autoestima cuando comparados a las mujeres. Conclusión: los pacientes con ansiedad y depresión fueron menos resilientes y presentaron mayor autoestima.

Abordaje de enfermeria a las dimensiones psicoemocionales de los pacientes con sindrome coronario / Nursing approach to dimensions psicoemocionales of patients with coronary syndrome

En el campo de la salud, las personalidades tambien han sido estudiadas como factores predisponentes en la aparición de algunas enfermedades. Existen investigaciones a cerca de la enfermedad coronaria y su relación con dos tipos de personalidades, personalidad A y personalidad B. La psicocardiología se conoce como la rama de la psicologia que detecta los factores de riesgo psicosociales que inciden en el desarrollo o desencadenamiento de las enfermedades cardiovasculares. En el presente trabajo se abordan los factores que repercuten en diferentes pacientes con padecimiento coronario asi como el vinculo de estos con los diferentes tipos de personalidades y rescatando que cuando cuidamos estos pacientes, debemos tener en cuenta aspectos importantes para minimizar el impacto emocional relacionado con el diagnóstico...

Study on Lifestyles and Stress Levels in Medicine Student / Estudo sobre Estilos de Vida e Níveis de Estresse em Estudantes de Medicina

Estilos de vida pouco saudáveis são fatores de risco preveníveis para doenças crônicas. Intervir sobre eles constitui estratégia fundamental de saúde preventiva. Objetivo: Avaliar o estilo de vida, os níveis de estresse, as doenças e os fatores de risco cardiovascular de estudantes de medicina. Métodos: Estudo transversal, observacional, com alunos de uma escola de medicina estratificados em: Grupo 1(G1) - do 1º ao 4º período do curso, Grupo 2 (G2) - do 5º ao 8º e Grupo 3 (G3) - do 9º ao 12º. Foram aplicados dois questionários: Estilo de vida Fantástico e outro relacionado a níveis de estresse, doenças e fatores de risco cardiovascular. Resultados: Foram avaliados 482 estudantes, média de idade 21,7±2,7 anos. A pontuação média no questionário Estilo de vida Fantástico classificou o G1 e o G3 em Muito bom (72,1 e 71,3 pontos, respectivamente) e o G2 em Bom (69,2 pontos) (p=0,007). Quanto aos níveis de estresse, responderam Alto ou Muito Alto 22,3% no G1, 34,9%no G2 e 30,7% no G3 (p=0,008). As doenças mais prevalentes foram dislipidemia (7,4%), hipertensão arterial (2,6%)e transtorno depressivo (2,2%). Conclusões: Houve piora considerável do estilo de vida e dos níveis de estresse a partir do 5º período, com melhora parcial nos dois últimos anos do curso. Observou-se expressiva prevalência de dislipidemia, hipertensão e transtorno depressivo...

Unhealthy lifestyles are preventable risk factors for chronic diseases. Intervening on them is a fundamental strategy of preventive health. Objective: To evaluate lifestyle, stress levels, diseases and cardiovascular risk factors of medical students. Methods: Cross-sectional, observational study with students from a medical school stratified into: Group 1 (G1) - from the 1st to the 4th period of the course, Group 2 (G2) - from the 5th to the 8th and Group 3 (G3) - from the 9th to the 12th. Two questionnaires were given: Fantastic Lifestyle and another one related to stress levels, diseases and cardiovascular risk factors. Results: The study included 482 students, average age 21.7±2.7 years. The average score on the Fantastic Lifestyle questionnaire ranked G1 and G3 at Very good (72.1 and 71.3 points, respectively) and G2 in Good (69.2 points) (p=0.007). As for the stress levels, they responded High or Very High 22.3% in G1, 34.9% in G2 and 30.7% in G3 (p=0.008). The most prevalent diseases were dyslipidemia (7.4%), hypertension (2.6%) and depressive disorder (2.2%). Conclusions: There was considerable worsening of lifestyle and stress levels from the 5th period, with partial improvement in the last two years of the course. There was a significant prevalence of dyslipidemia, hypertension and depressive disorder...